The Best Travel Hotel / Motel Deals on the Web!   All Countries > United States > Missouri > Cape Girardeau > Holiday Inn Arrival Date Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Departure Date Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Adults 1 2 3 4 Children 0 1 2 3 4 Holiday Inn - Cape Girardeau Missouri Holiday Inn Express Hotel & Suites CAPE GIRARDEAU I-55 3253 WILLIAM ST. Cape Girardeau, MO 63701 Nightly Rates (101.95 - 175.00)   3 Star Welcome to the Holiday Inn Express Hotel & Suites Cape Girardeau. This newly built Cape Girardeau hotel opened in June 2005. Conveniently located at Interstate 55 and William St. (exit 96). The hotel is just minutes from Southeast Missouri ...more Nearby Cities: Anna ,  Cairo ,  Ullin ,  Cape Girardeau ,  Jackson Cape Girardeau Hotel Chains Drury HotelsHoliday InnSuper 8 MotelsUnirez by Pegasus